Definition: Predisruption is a medical term used to describe the condition where an individual's immune response to a particular disease or infection is altered or suppressed. It occurs when the body does not respond appropriately to a specific pathogen, leading to symptoms such as fever, malaise, and fatigue that are characteristic of the disease. In some cases, predisruption may be due to a genetic factor or environmental factors that can influence an individual's immune system response to a particular infection.