👉 Coates' disease, also known as Coats' syndrome, is a rare genetic condition characterized by developmental abnormalities in the brain and spinal cord. It affects approximately 1 in 250,000 individuals worldwide, resulting in intellectual disability, severe cognitive impairment, and various neurological symptoms such as seizures, ataxia, and spasticity. This condition typically begins in childhood or adolescence and is often diagnosed through genetic testing, with the presence of mutations in genes that are responsible for