Definition: Leukoderma is a rare and often life-threatening skin condition that occurs in the skin of the cheeks, chin, and neck. The condition can be caused by an infection or inflammation within the skin's epidermis (the outermost layer). It typically affects young children but can also occur in adults who are immunocompromised or have other health issues. The symptoms of leukoderma include redness, swelling, and pain in these areas. Some people may experience itching or burning sensations